Ldb1 regulates carbonic anhydrase 1 during erythroid differentiation
نویسندگان
چکیده
منابع مشابه
GATA-1 directly regulates p21 gene expression during erythroid differentiation.
Lineage-determination transcription factors coordinate cell differentiation and proliferation by controlling the synthesis of lineage-specific gene products as well as cell cycle regulators. GATA-1 is a master regulator of erythropoiesis. Its role in regulating erythroid-specific genes has been extensively studied, whereas its role in controlling genes that regulate cell proliferation is less u...
متن کاملCarbonic Anhydrase I is an Early Specific Marker of Normal Human Erythroid Differentiation
The expression of carbonic anhydrase (CA) as a marker of erythroid differentiation was investigated by immunologic and enzymatic procedures. A polyclonal anti-CA antibody was obtained by immunizing rabbits with purified CA I isozyme. This antibody is reactive with CA I but not with CA II. Within blood cells. CA I was only present in erythrocytes. whereas CA II was also detected in platelet lysa...
متن کاملCarbonic anhydrase I is an early specific marker of normal human erythroid differentiation.
The expression of carbonic anhydrase (CA) as a marker of erythroid differentiation was investigated by immunologic and enzymatic procedures. A polyclonal anti-CA antibody was obtained by immunizing rabbits with purified CA I isozyme. This antibody is reactive with CA I but not with CA II. Within blood cells, CA I was only present in erythrocytes, whereas CA II was also detected in platelet lysa...
متن کاملCarbonic anhydrase isoenzymes I and II in rabbit erythroid cells.
The morphological and cytochemical changes in erythroid-cell differentiation have been extensively studied: application of the velocity-sedimentation technique has provided preliminary data on the associated biochemical changes (Denton & Arnstein, 1973). After the last cell division there is a dramatic increase in the synthesis of haemoglobin which, at least in part, probably accounts for the a...
متن کاملMultiple functions of Ldb1 required for beta-globin activation during erythroid differentiation.
Ldb1 and erythroid partners SCL, GATA-1, and LMO2 form a complex that is required to establish spatial proximity between the β-globin locus control region and gene and for transcription activation during erythroid differentiation. Here we show that Ldb1 controls gene expression at multiple levels. Ldb1 stabilizes its erythroid complex partners on β-globin chromatin, even though it is not one of...
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ژورنال
عنوان ژورنال: Biochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanisms
سال: 2012
ISSN: 1874-9399
DOI: 10.1016/j.bbagrm.2012.05.001